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In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression

S Khurana and A Bokkers and DJ Geijs and S Schivo and M Karperien and JN Post (2019), Osteoarthritis and cartilage, 27, S193--S194, Elsevier

Uses an in silico model of the cartilage circadian clock to show that mutating BMAL1 raises MMP expression, linking clock disruption to cartilage breakdown.